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Type d'Item : Item , Does a Regular Menstrual Tampon or an Intravaginal Pessary Mitigate Urine Leakage While Running Among Females Who Experience Exercise-Induced Urinary Incontinence?(Université d'Ottawa / University of Ottawa, 2026-09-08) Collins, Grace; McLean, LindaExercise-induced urinary incontinence (EI-UI), urine leakage experienced predominantly during exercise, affects nearly 40% of females who participate in high-impact activities and is a common barrier to exercise participation. In this randomized assessor-blind crossover trial, 30 adult females with EI-UI completed three standardized treadmill protocols: one without intervention, one with a self-fitted Uresta® pessary, and one with a regular menstrual tampon, with the latter two administered in randomized order. The primary outcome was the EI-UI Severity Index, a composite of self-reported leakage frequency and perceived volume during the run. Secondary outcomes included pad weight gain during the run, exercise-induced pelvic floor tissue strain assessed via transperineal ultrasound imaging, and user self-reported experience. Both devices significantly reduced EI-UI Severity Index scores compared to no intervention, with the pessary offering significantly greater symptom reduction compared to the tampon. The pessary significantly reduced pad weight gain while the tampon did not. Neither device influenced the extent of exercise-induced pelvic floor tissue strain. These findings support the use of the self-fitted Uresta® pessary and a regular menstrual tampon as effective, self-administered conservative management strategies for EI-UI in active females, with the pessary being superior to a menstrual tampon.Type d'Item : Item , Investigating Glioblastoma Invasiveness in a Mouse Model of Neurovascular Deficiency(Université d'Ottawa | University of Ottawa, 2026-09-08) Matthews, Taj; Lacoste, Baptiste; Lorimer, IanGlioblastoma is the most common malignant brain tumour and has the lowest 5-year survival rate among CNS tumours at only 4.9%. A key driver of glioblastoma development is the vasculature, which it relies on heavily due to the lack of energy storage in brain tissue. Glioblastoma uses several different methods of angiogenesis to address the metabolic needs of tumour growth. Given how reliant this type of cancer is on its angiogenic and metabolic activity, it would be intriguing to see how glioblastoma progression changes when these factors are perturbed. 16p11.2 deletion syndrome is a copy number variation which has been associated with many different developmental conditions. While most of the work associated with this deletion syndrome is associated with autism spectrum disorder, we are interested in the cerebrovascular and metabolic alterations associated with the deletion. Our lab has demonstrated that 16p11.2-haploinsufficient (16p11.2df/+) mice have pertinent neurovascular and metabolic deficits, which make this mouse model a candidate for studies involving glioblastoma. Using the Wiesner model of glioblastoma induction, we sought to assess whether glioblastoma progression would be hindered in 16p11.2df/+ mice compared to WT mice. After assessing the subventricular zone for differences in morphology and relevant cell populations, we used the Wiesner model in 16p11.2df/+ mice and successfully induced both wild-type and 16p11.2df/+ mice. Within these groups, 16p11.2df/+ mice were found to have reduced GFP+ cell expression, reduced bulk tumour tissue area, and altered morphology of the tumour vasculature. Taken altogether, our findings suggest that genes within the 16p11.2 locus may contribute to glioblastoma-associated vascular remodeling.Type d'Item : Item , Handmade to Ready-made: A Shift in Canadian Women’s Sewing and Consumer Education (1950-1975)(Université d'Ottawa | University of Ottawa, 2026-09-08) Hancock, Alexandra; Templier, Sarah; Seferdjeli, RymeWhen did sewing become a niche hobby in Canada? How did the practice of sewing go from a common skill to all but disappearing in the average Canadian home? This thesis seeks to explore the shift from handmaking clothing to buying primarily ready-made fashion in Canada from 1950-1975. This project will address these questions through an examination of sewing and consumer education in different versions of the Ontario Home Economics curriculum, and Canadian consumer consciousness through advice from Chatelaine, a popular Canadian women’s magazine. Discourses around quality both in terms of consuming and in terms of appearance and character help understand changes in attitudes towards sewing and purchasing clothing. This project examines the strong gendered norms and stereotypes associated with Home Economics, sewing, and reading Chatelaine. The impact of the women’s movement and the 1970 Report of the Royal Commission on the Status of Women in Canada will be studied in terms of their effect on sewing, consumer education, and the breakdown of Home Economics as a field. This thesis situates the decline of sewing skills in the context of weakening of Home Economics education, the increase of mass consumption in Canada and a decline in overall quality in clothing. This project reveals the consumer advice from the 1950-1975, centred around consuming slowly and thoughtfully, has modern relevance in the context of fast fashion and climate change.Type d'Item : Item , Vancomycin optimised dosing regimens for critically ill patients receiving renal replacement therapy(2026-08-04) Ulldemolins, Marta; Lipman, Jeffrey; Liu, Xin; Abdul-Aziz, Mohd-Hafiz; Baptista, João P.; Bilgrami, Irma; Bitker, Laurent; Boidin, Clement; Brinkmann, Alexander; Cheng, Vesa; Choi, Gordon; Cole, C. Louise; De Waele, Jan J.; Deans, Renae; Eastwood, Glenn M.; Escobar, Leslie; Frey, Otto R.; Garreau, Romain; Goutelle, Sylvain; Gresham, Rebecca; Hernandez-Mitre, Maria P.; Jamal, Janattul A.; Joynt, Gavin M.; Kanji, Salmaan; Kielstein, Jan T.; Kluge, Stefan; König, Christina; Koulouras, Vasilios P.; Lassig-Smith, Melissa; Laterre, Pierre-Francois; Lee, Anna; Lefrant, Jean-Yves; Lei, Katie; Leung, Patricia; Mat-Nor, Mohd-Basri; Mudaliar, Yugan; Ostermann, Marlies; Paul, Sanjoy K.; Peake, Sandra L.; Rello, Jordi; Richard, Jean-Christophe; Richards, Brent; Roberts, Darren M.; Roberts, Michael S.; Roehr, Anka C.; Roger, Claire; Seoane, Leonardo; Shekar, Kiran; Sinnollareddy, Mahipal; Sousa, Eduardo; Spring, Anna; Starr, Therese; Stephens, Dianne; Taccone, Fabio S.; Thomas, Jane; Turnidge, John; Valkonen, Miia; Wallis, Steven C.; Williams, Tricia; Wittebole, Xavier; Wright, Daniel F. B.; Zikou, Xanthi T.; Roberts, Jason A.Abstract Background Optimal dosing of vancomycin in critically ill patients receiving renal replacement therapy (RRT) is uncertain due to high pharmacokinetic variability. We aimed to develop individualised vancomycin dosing recommendations that optimise efficacy while minimising toxicity. Methods Prospective, international, pharmacokinetic study enrolling critically ill patients treated with vancomycin and various RRT modalities. A population pharmacokinetic model was developed, externally validated and applied to perform Monte Carlo dosing simulations. We calculated the probability of each dosing regimen to achieve the efficacy target against methicillin-resistant Staphylococcus aureus (ratio of the area under the concentration–time curve to the minimum inhibitory concentration (AUC0-24 h/MIC) ≥ 400) without exceeding the toxicity threshold (AUC0-24 h ≥ 700 mg.h/L). Results We enrolled 65 critically ill patients from 6 countries receiving continuous RRT (50.8%) or sustained low-efficiency dialysis (49.2%). The model was developed using 1318 pre- and post-filter plasma and effluent concentrations and validated with a new dataset (19 critically ill patients, 124 pre-filter plasma concentrations), with 47.4% patients concomitantly treated with extracorporeal membrane oxygenation. Predictive performance was high (median prediction error =—13.4%). Simulations showed that dosing requirements were dependent on actual body weight and RRT intensity and duration (p < 0.05). An optimised dosing nomogram was subsequently developed considering these clinical characteristics. Conclusions Actual body weight and RRT intensity and duration are the main determinants of vancomycin dosing requirements in critically ill patients treated with RRT. Efficacious, non-toxic dosing may be guided by the optimised nomogram.Type d'Item : Item , Advancing palliative medicine training in adolescent and young adult care: a needs assessment study(2026-06-22) Bakhsh, Abdulaziz; Srikanthan, Amirrtha; Cleyn, Sarah; van Zanten, Stephanie C. V.; Tutelman, Perri; Krueger-Naug, Anne M.; Parsons, Henrique; Lapenskie, Julie; Ruller, Sydney; Halman, Samantha; Downar, James; Abdelaal, MohamedAbstract Background Adolescents and young adults (AYAs), defined as individuals aged 15–39 years, face unique medical, psychosocial, and existential challenges when living with life-limiting illness. Despite evidence supporting early palliative care integration, Canadian adult palliative care curricula lack formalized AYA-specific competencies. Healthcare providers consistently report insufficient preparation in this area. Methods A descriptive cross-sectional needs assessment survey was administered nationally to physicians who completed Canadian adult palliative care residency training between 2019 and 2024. A multidisciplinary steering committee of experts in AYA palliative care and medical education, alongside a patient partner, guided the development of the bilingual 25-item questionnaire guided by an established framework for medical education survey design. The questionnaire assessed clinical exposure, self-rated knowledge across 20 competency areas, comfort levels across 21 competency areas, training needs and barriers, and preferred learning formats. Responses were anonymous. Descriptive statistics were used for analysis. Results Of 71 responses received, 55 met eligibility criteria for analysis (response rate 35%, eligibility rate 77%). Only 31% of participants received AYA-specific training during residency. Most participants (82%) reported low comfort when caring for the youngest AYA age group (15–18 years). The greatest knowledge gaps were in pediatric-to-adult care transitions (69%), sexual health and fertility concerns (62%), and social support navigation (39%). Top training priorities were AYA developmental and psychosocial factors (75%), grief and bereavement support (65%), and care transitions (60%). The most common training barriers were limited clinical exposure (78%), lack of mentors (65%), and absence of AYA-specific programs (61%). Conclusions Our findings revealed substantial gaps in training, knowledge, and comfort levels in providing AYA palliative care among recent graduates from the adult palliative care programs in Canada. This may represent an initial step towards the development of a competency-based AYA-focused residency training curriculum.