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Type d'Item : Item , Integrating Global Knowledge for Dual Value Creation An Interdisciplinary Framework for Practice-Informed Social Entrepreneurship EducationBrkic, Tatjana; Szostak, RichardSocial entrepreneurship (SE) has long demonstrated that social and economic value can be created simultaneously through enterprises generating both community benefit and financial sustainability. Despite the persistence of this practice across cultures, regions, and historical periods, SE scholarship and Social Entrepreneurship Education (SEE) remain fragmented by disciplinary boundaries, competing definitions, and regionally specific models that limit the scaling of SE practice and the development of a coherent and globally applicable SEE approach capable of supporting solutions to complex global problems. This dissertation addresses the absence of an integrated, interdisciplinary, and globally transferable SEE framework aligned with a complementary pedagogical design. Guided by the Interdisciplinary Research Process (IRP) (Repko & Szostak, 2025), the research integrates disciplinary scholarship, regional educational practice, cultural philosophies, and practitioner knowledge. The study was conducted across three research phases, including interdisciplinary theoretical integration, comparative empirical investigation of SEE ecosystems in Manitoba, Prince Edward Island, Croatia, and Slovenia, and iterative implementation and evaluation of the resulting SEE approach across multicultural and multidisciplinary learning environments. The dissertation applies redefinition as an IRP integration strategy to establish a globally applicable understanding of SE practices capable of supporting cross regional investigation. Systems theory and complexity science are subsequently applied as integrative lenses to develop a shared theoretical foundation for interpreting SE as a process emerging through interactions across ecological, social, and economic systems rather than as a normative aspiration. The research further identifies the nested hierarchy of open systems as the broader systems configuration within which social enterprises operate and distinguishes systemic conditions governing cross system interactions from context specific socioeconomic variables shaped through institutional and societal design. The resulting SEE framework organises knowledge into multilevel theoretical and applied domains while distinguishing between globally applicable and context specific knowledge in order to remain transferable across regions and responsive to different cultural contexts. The framework integrates practitioner derived and research derived knowledge within a single educational architecture that was tested and refined through five implementations involving learners across Europe, Asia, North America, and South America. Findings indicate that dual value creation in entrepreneurial practice, is consistently recognised across culturally diverse learner groups and regional contexts, providing preliminary empirical support for the broader applicability of the proposed SEE framework. The dissertation contributes a theoretical proposition positioning SE as a structurally necessary complex phenomenon and social enterprises as complex open systems embedded within a nested hierarchy of open systems, with systemic conditions governing social and economic value creation. The research further proposes a typology of social enterprises distinguishing integration and coordination mechanisms of dual value creation, alongside the integration of cultural philosophies into the SEE knowledge architecture. The findings suggest that culturally grounded traditions across regions independently developed practices aligned with dual value creation long before the emergence of formal SE scholarship. The dissertation concludes by advancing an interdisciplinary integrated SEE framework that may provide a promising direction for further interdisciplinary research, educational design, and the development of SE practice across diverse institutional and cultural contexts.Type d'Item : Item , Between Abandonment and Reappropriation: Renegotiating with the Afterlives of Ruin Landscapes on the Islands of Naoshima, Teshima, and Inujima(Université d'Ottawa / University of Ottawa, 2026-09-22) Vaillancourt, Josée; Mirza, VincentThis thesis follows the afterlives of industrial and demographic ruination on the islands of Naoshima, Teshima, and Inujima in Japan's Seto Inland Sea, where abandoned structures and ruin landscapes have been drawn back into use through site specific art projects. Approaching these islands as patchy, haunted ruin landscapes shaped by overlapping histories of extraction, shrinkage, and more than human reoccupation, this thesis argues that maintenance work has become a central practice through which these places are reinhabited and folded into new arrangements of living. Based on ethnographic fieldwork conducted on these islands during the Setouchi Triennale 2022, I follow maintenance work as a practice of ongoing (re)negotiation between abandonment and reappropriation, between human withdrawal and more than human activity, and between industrial pasts and curated and imagined futures. Across industrial slag landscapes, restored rice paddies, and repurposed akiya, I show how maintenance work engages with the shifting relations that constitute these landscapes, shaping their afterlives and the forms of habitability that persist within them at a time of rural shrinkage and the Anthropocene.Type d'Item : Item , The epidemiological impact, costs, and cost-effectiveness of implementing household contact investigation with tuberculosis preventive treatment in Nepal: a model-based analysis(2026-09-15) Paudel, Rajan; Thapa, Anchal; Shrestha, Suvesh; Dorjee, Kunchok; Dhital, Raghu; Dowdy, David W.; Caws, Maxine; Shrestha, SouryaAbstract Background The burden of tuberculosis (TB) remains extremely high globally. It is increasingly recognized that contact investigation and preventive treatment are essential components of effective action to reduce TB. High-quality, local evidence of feasibility and impact is urgently needed to catalyse scale-up of preventive treatment in high-burden, resource-constrained settings. Methods We collected data on the costs and yields of contact investigation and implementation of three months of isoniazid and rifapentine (3HP) to treat latent TB infection (LTBI), among adult household members of people diagnosed with TB, from a pilot conducted in two districts of Nepal (Chitwan and Pyuthan) from August 2022 to March 2023. We developed and calibrated mathematical models representing each district and estimated the number of TB episodes and deaths averted by the intervention during 2023–2042. By combining net discounted costs and discounted impact, we estimated the incremental cost-effectiveness of the intervention (compared to no intervention) from a health system perspective as costs (United States Dollars (USD) in 2022) per disability-adjusted life-year (DALY) averted. Results The intervention screened 1,711 adult household contact persons for TB and LTBI, and treated 500 individuals for LTBI, achieving 98% 3HP acceptance and 95% completion at 150 USD per contact person treated (including drug and test procurement and implementation costs). Including the impact of treating TB disease, the intervention was projected to avert 141 (95% Uncertainty Interval (UI): 86–224) disease episodes and 24 (95% UI: 13–39) deaths during 2023–2042, or 8.2 episodes and 1.4 deaths averted per 100 contact persons screened. The incremental cost-effectiveness of the intervention was 119 USD (95% UI: 51–255) and 163 USD (95% UI: 76–328) per DALY averted in Chitwan and Pyuthan, respectively. Conclusions Screening and treating household members of people with TB for both TB and LTBI can be successfully implemented in both rural and urban settings, is highly cost-effective and should be prioritized to reduce the TB burden in Nepal and similar high-burden countries.Type d'Item : Item , Implementing Canadian practice guidelines for children and adolescents with eating disorders: a qualitative study on barriers, facilitating factors and implementation strategies(2026-05-20) Couturier, Jennifer; Nicula, Maria; Nella, Ethan; Yanover, Tovah; Kimber, Melissa; Coelho, Jennifer; Dimitropoulos, Gina; Kurji, Ayisha; Boman, Jonathan; Isserlin, Leanna; Bond, Jason; Agostino, Holly; Soroka, Chelcie; Lacroix, Emilie; Annema, Stephanie; Boachie, Ahmed; McVey, Gail; Norris, Mark; Obeid, Nicole; Pilon, David; Spettigue, Wendy; Findlay, Sheri; Geller, Josie; Grewal, Seena; Gusella, Joanne; Jericho, Monique; Johnson, Natasha; Katzman, Debra K.; Leclerc, Anick; Webb, Cheryl; Brouwers, MelissaAbstract Background In Canada, access to timely, evidence-based care for eating disorders is limited, with long wait times and fragmented services. Clinical practice guidelines can improve consistency and quality of care, but successful implementation remains limited. Canadian practice guidelines and a virtual care addendum have been developed for the treatment of youth with eating disorders (EDs). This study aims to qualitatively seek perspectives on the barriers, facilitating factors and implementation strategies from various interested parties. Methods One semi-structured qualitative focus group was conducted in each of nine Canadian provinces. Focus groups consisted of a combination of clinicians, administrators, and individuals with lived experience who elaborated upon barriers and facilitating factors to guideline uptake as well as possible strategies to enhance implementation. Focus group transcripts were analyzed using conventional content analysis. Results Findings suggested that participants found it difficult to implement guideline recommendations due to a myriad of factors such as a lack of external resources and minimal training in guideline recommended therapies. Facilitating factors of uptake included support from leadership and explicit training on guideline therapies. Potential implementation strategies included the creation of adapted versions for families and healthcare professionals, as well as enhanced education materials. Conclusions The findings of this study indicate areas within healthcare provision that can be enhanced and expanded upon to further enhance the uptake of the Canadian practice guidelines for children and adolescents with eating disorders.Type d'Item : Item , Regenerative Index: a method to assess muscle regeneration in patients with Duchenne muscular dystrophy(2026-07-01) Smid, Johnathan K.; McPherson, Charis A.; Monast, Jacob G.; Rayagiri, Shanti S. S.; Moore, Steven A.; Rudnicki, Michael A.Abstract Background Duchenne muscular dystrophy (DMD) is a devastating disease manifested in skeletal muscle by repetitious myonecrosis and regeneration. Because the regenerative process is closely linked to the cumulative severity of muscle damage, which is variably distributed within and between muscle groups, accurately quantifying muscle regeneration has remained a significant challenge. Methods Myofibers are delineated by immunostaining for laminin, and subsequent image analysis employed to generate a masked outline precisely within each myofiber boundary. Morphometric parameters including minimal Feret’s diameter, cross-sectional area, and circularity were measured for each myofiber. In addition, the number of Pax7-expressing satellite cells were quantified. To evaluate regenerative activity, newly formed myofibers were identified by immunostaining for expression of embryonic myosin heavy chain (eMHC). Necrotic myofibers were enumerated by immunofluorescent detection of immunoglobulin G (IgG) infiltration. The Regenerative Index (RI) was calculated as the number of regenerating (eMHC+) myofibers divided by the number of necrotic (IgG+) myofibers. Determination of RI was performed on muscle biopsies obtained from 10 boys with DMD and 3 age-matched non-DMD controls. Results A trend toward an increasing minimal Feret’s diameter, cross-sectional area and circularity was observed with increasing age in DMD boys, with circularity showing the strongest trend. Furthermore, compared to DMD boys 7- to 8-years old, the boys 9- to 11-years old had increased myofiber circularity. Pax7-expressing cells per myofiber were elevated in DMD boys compared to control boys of similar ages, without any observation of age-related changes. The Regenerative Index in DMD boys exhibited a decline between 7 and 11 years of age, with an inverse correlation between RI and age. Conclusions The use of eMHC and IgG immunostaining to calculate RI appears to provide a way to assess regeneration across biopsies that differ in histopathologic severity. Using this approach, RI showed a negative correlation with age in DMD boys aged 7 to 11 years which requires further investigation.