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Type d'Item : Item , I Don't Suffer from Dyslexia; I Suffer from Other People: A Study on Students with Dyslexia and Stigma Experiences in Canadian Universities(Université d'Ottawa / University of Ottawa, 2026-09-15) Rao, Marcus; Orsini, MichaelThis thesis examines how students who identify as dyslexic experience academic accommodation systems in Canadian universities, and how these systems shape experiences of stigma, disclosure, identity, and belonging. Guided by an intersectional disability studies framework, the study analyzes eight semi-structured interviews with students across Canadian post-secondary institutions. Findings reveal that accommodation systems, while legally mandated and necessary, operate within and often reproduce ableist institutional norms that position neurotypical ways of learning and performing as the standard. Experiences of stigma and identity negotiation were produced through accommodation processes themselves, shaped by intersecting systems of ableism, racism, and gendered and classed expectations embedded within higher education. Access depended not only on accommodations themselves but on the institutional conditions, relationships, and ongoing labour required to activate them. This study contributes to Disability Studies and the sociology of education by centering diverse students' voices within Canada's fragmented disability policy landscape.Type d'Item : Item , Exploring Patients' Experiences with Medication Abortion Care in Quebec: A Multi-Method Study(Université d'Ottawa / University of Ottawa, 2026-09-15) Sauvé, Camille; Foster, Angel M.In Canada, two methods of abortion are currently available: instrumentation (surgical) and medication. Most medication abortions consist of the mifepristone/misoprostol regimen. The availability of this care is influenced by a combination of federal drug approval and provincial service delivery. Although the medication abortion regimen is highly safe and effective during the first trimester and covered through provincial and federal insurance schemes, persistent geographic and socioeconomic disparities create ongoing barriers to access, including for individuals residing in rural areas. This multi-method study aimed to evaluate the current state of knowledge regarding abortion care in Quebec and explore the medication abortion care delivery experiences of women, transgender men, and others with the capacity for pregnancy (womxn). We conducted a scoping review alongside in-depth, semi-structured interviews with womxn who obtained medication abortion pills in Quebec since the introduction of mifepristone in Canada in 2017. The results of this study characterize distinct challenges shaped by different lived experiences and provide implications for future action-oriented research to further enhance the quality, accessibility, acceptability, and destigmatization of abortion services in Quebec.Type d'Item : Item , Epistemic Authority, Moral Interpretation, and Probability in Eliza Haywood's The Invisible Spy(Université d'Ottawa / University of Ottawa, 2026-09-15) Guindon-Gough, Luna; Landreth, SaraExploralibus, the narrator of Eliza Haywood's Invisible Spy (1754), acquires an invisibility belt and recording tablet, which he uses to discover secrets that he believes will entertain and educate the public. Yet, in order to erase the tablet, Exploralibus must purchase a three-year-old girl and raise her so that she has no concept of gender difference. Through this frame narrative, Haywood undermines Exploralibus's moral authority by showing that he is willing to abuse a young girl to pursue his literary career. My methodology draws on historical epistemology, the history of genre, and proto-feminism to analyze the purpose of Exploralibus's hypocrisy. I discuss how Haywood uses allusions to The Spectator (1711-14), The New Atalantis (1709), and the Canning case (1753-54) to craft a generically complex miscellany. I argue that Haywood aims to teach readers how to judge the believability of any given story for themselves instead of relying on problematic narrators.Type d'Item : Item , Retrofitting CLT Panels and Glulam Beams Subjected to Static and Dynamic Loads(Université d'Ottawa / University of Ottawa, 2026-09-15) Hosseinian Ahangarnazhad, Bita; Doudak, GhasanMass timber products such as cross-laminated timber (CLT) and glued laminated timber (glulam) have become more common in contemporary structures, particularly mid- to high-rise ones, as a result of their development. Although engineered wood products are structurally efficient and reliable, their performance can deteriorate over time due to factors such as material deterioration, increased service demands, and exposure to extreme loading conditions. As a result, research on strengthening and rehabilitating timber members has gained significant attention in structural engineering. The current research aims to investigate the effect of CFRP in improving the structural performance of CLT panels and glulam beams under static and dynamic blast loads. Experiments were conducted at the University of Ottawa using a shock tube designed to replicate the high strain rates associated with blast loading. Different retrofit configurations were investigated, including confinement only and combined configurations with both unidirectional tension reinforcement and CFRP confinement. The confinement was applied in various configurations, including full length, localized (shear and moment regions), and U-shaped arrangements, using both unidirectional and bidirectional CFRP. According to the experimental results, CFRP fabrics significantly improved the resistance, stiffness, and ductility of the specimens. In the static tests, the retrofitted CLT specimens exhibited increases in peak resistance from 13% to 133%, while stiffness improvements reached up to 49%. The ductility ratio increased to a maximum of 1.67, indicating enhanced energy absorption. Under dynamic loading, peak resistance increased up to 166%, while stiffness improvement reached up to about 52%. In addition, the failure mode shifted from rolling shear in the unretrofitted CLT panel to predominantly flexural behavior in the retrofitted ones. For the glulam specimens, the retrofitting led to peak resistance and stiffness increases up to 46% and 13%, respectively, under static loading. Under dynamic loading, peak resistance increased by up to 123%, with the failure modes primarily governed by flexural behavior. A fiber section analytical model was developed to simulate the behaviour of the specimens up to peak resistance. The predictions showed good agreement with experimental data, accurately reflecting force response, stiffness, and displacement at peak resistance.Type d'Item : Item , Examining Post-Operative Antigen Specific CD8⁺ T Cell Dysfunction(Université d'Ottawa / University of Ottawa, 2026-09-15) Olanubi, Oladunni; Auer, Rebecca C.Surgery remains the most effective approach to cure patients with solid malignancies. However, surgical trauma results in significant cellular immunosuppression. CD8⁺ T cell dysfunction post-operatively has been characterized, however the effects of surgery on antigen specific CD8⁺ T cell suppression has not been fully explored. Here, we established that surgery-induces antigen specific CD8⁺ T cell dysfunction, including impaired pro-inflammatory cytokine secretion and cytotoxicity in patients and mice. We developed a model to investigate surgical stress and cancer recurrence in C57Bl/6 mice, based on transfer of CD8⁺ OT-I T cells, reactive to ovalbumin (OVA), followed by challenge with B16-OVA melanoma cells. This model demonstrates 100% protection against cancer in control animals but 0% protection following surgery. Using a COVID-19 immunological tool kit to characterize post-operative function, we observed a significant suppression in T cells from vaccinated cancer patients. The OT-I model was used to evaluate the mechanisms of post-operative T cell dysfunction. We first established that a population of surgery induce Myeloid Derived Suppressor Cells (sxMDSCs) also known as GR-1⁺ cells in mice which expand after surgery in mice and cancer patients on post-operative day 1 (POD1), are suppressive of CD8⁺ T cells. We then performed single cell RNA sequencing, which identified the intracellular checkpoint CISH (Cytokine-inducible SH2-containing protein) as upregulated in antigen-stimulated human and murine CD8⁺ T cells following surgical stress. Overall, this work highlights antigen specific CD8⁺ T dysfunction post-operatively and uncovers a possible mechanism of dysfunction characterized by the expression of an intracellular checkpoint CISH.