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Type d'Item : Item , Investigating Heparin Dynamics through Solid-State Nanopores: Toward Nanopore-based Methods for Glycomics(Université d'Ottawa | University of Ottawa, 2026-09-10) Zhao, Kexin; Tabard-Cossa, VincentSolid-state nanopores have become a fast-rising technique in single-molecule sensing, especially in DNA and protein sensing. Carbohydrates, as one of the most important biomacromolecules for human life, have posed challenges in related research and analysis due to their complexities, and solid-state nanopores have shown great potential in glycan sensing and analysis because of their stability, cost-effectiveness, fast results and high sensitivity. The kinetics, conformation, and identification of heparin molecules were investigated. Heparin is a widely used anticoagulant in medical practices, and a large-scale contamination scandal in 2008 has attracted more attention, as a quick and effective method to differentiate heparin and OSCS (oversulphated chondroitin sulphate) needs to be developed. A series of experiments was done in different salts and salt concentrations, at different pH levels, to find an optimized sensing condition for maximum capture. By a simulation tool developed in the lab and the experimental results, we also investigated conformations of heparin as they pass through a solid-state nanopore. However, the negatively charged small particles pass through the nanopores too fast for the state-of-the-art instruments to fully resolve. An attempt was also made to differentiate heparin and OSCS, but no significant differences were seen. In an effort to slow down the molecules, a specialized flow cell that incorporates a pressure system was adopted. However, under a small counterpressure, heparin molecules were not seen to slow down. Lectin, a human protein that has proved to be heparin-binding, was also experimented with. It was shown that at 3.6 M LiCl, pH 4, heparin and lectin molecules could bind and form a compound that translocates through the nanopore as one, which produces significantly slower and deeper signals.Type d'Item : Item , Ship Wake Influence on Fish Communities in the Upper St. Lawrence River(Université d'Ottawa | University of Ottawa, 2026-09-10) Stephenson, Taylor; Rennie, Colin; Nistor, IoanThe St. Lawrence River is home to large vessels that travel between the Atlantic Ocean and the Great Lakes. Ships that travel throughout the waterway generate both primary and secondary waves that travel towards the nearshore ecosystem, disrupting the fish communities. With the increase in novelty of ship hydrodynamics and ecology, this is the first study that incorporates both disciplines into one. The Upper St. Lawrence River is an ideal river for surveying as it spans over 240 kilometres long and up to 7 kilometres wide. The Fish Identification Nearshore (FINS) research team at the St. Lawrence River Institute surveyed over 230 sample locations to perform more than 600 fish surveys. In their database, they contain data for fish surveying through abundance (the total fish count) and richness (total fish species) at each site location, environmental DNA (eDNA) sampling, water quality measurements, habitat and vegetation sampling, and drone imaging. This research uses the FINS database to find correlations between the ships that travel throughout the Upper St. Lawrence River and the data within the database. The primary analysis of this research is to find correlations based on direct exposure to the shipping lane and the distance to the shipping lane from the designated site locations. Secondary analyses consist of exposed site locations within 1 kilometre of the shipping lane for: (1) the coastline geometry classified as straight shoreline or embayment shoreline, and (2) the dominant substrate, and (3) the habitat type classified as wetland or non-wetlands. Four different statistical analyses were used depending on the distribution of fish abundance and fish richness: (1) regression slope analysis for R^2 correlations, (2) analysis of variance (ANOVA) for normal distributions, and nonparametric methods for skewed distributions of (3) Mann-Whitney U testing for categories with two independent groups, and (4) Kruskal-Wallis H testing for categories with more than two independent groups. Probability values where the value was less than 0.05 demonstrated statistically significant results. Effect sizes accompanied the probability values. Results demonstrated the following outcomes: (1) a negative correlation between fish richness and proximity of ships towards the shoreline, (2) higher fish richness at exposed embayment site locations compared to straight shorelines, (3) higher fish richness with site locations primarily consisting of finer grain sizes (sand and clay) and lower fish richness with site locations with site locations consisting of coarser grain sizes (cobble and gravel), and (4) habitat type did not deliver statistically significant results. In summary, sites close to the shipping lane with rocky straight shorelines were found to have reduced fish community abundance and diversity, presumably due to the influence of nearshore wave action.Type d'Item : Item , Chronic Emptiness as Disintegration and Survival: A Grounded Theory of the Unanchored Self in People Diagnosed with Borderline Personality Disorder(2026-09-10) Kafi, Sogol; Wiebe, StephanieChronic emptiness is a central yet insufficiently understood feature of borderline personality disorder (BPD). This study investigates the developmental, relational, and embodied foundations of chronic emptiness and advances a grounded theory conceptualized as The Unanchored Self. Eighteen qualitative interviews were conducted with six women diagnosed with BPD; each was interviewed three times. Using grounded theory methodology, the analysis identified recurring experiential patterns and integrated participants’ narratives with psychoanalytic, attachment-based, and trauma-informed perspectives. The resulting theory is grounded in participants’ own meanings and relational contexts, offering a nuanced account of emptiness as a dynamic experience emerging at the intersection of self-development, interpersonal patterns, and embodied ways of being. Five interrelated categories structure the theory: Embodiment of Chronic Emptiness, Relational Instability, Coping and Survival Strategies, Meaning Making, and Developmental Trajectory. Embodiment captured emptiness as a somatically encoded disruption of selfhood, marked by numbness, pain, and dissociation. Relational Instability reflected anticipatory withdrawal, abandonment expectations, and hypervigilance rooted in disrupted attachment. Coping and Survival Strategies described efforts to manage internal collapse through adaptive and maladaptive means, including avoidance, suppression, and self-harm. Meaning-making identified emptiness as a barrier to symbolic engagement and existential coherence. The Developmental Trajectory traced the emergence of emptiness to early relational trauma, emotional silencing, and environmental instability, culminating in a developmental model called Fragmented Foundation. Theoretical integration suggests that chronic emptiness serves as both a wound and a survival adaptation, a cyclical collapse of relational, somatic, and affective integration, sustained by coping strategies that echo early developmental fragmentation. Clinically, the findings underscore the need for trauma-informed, relationally attuned, and somatically grounded approaches that prioritize rupture–repair processes and the restoration of epistemic trust.Type d'Item : Item , Physical Literacy for Older Adults: A Call for Inter-Active Living(2026) Lloyd, Rebecca; Smith, Stephen; Belalcazar, Catalina; Milner, ColinImagining oneself in later life can evoke powerful feelings and perceptions about aging, movement, and engagement. This chapter explores physical literacy for older adults through the Function2Flow framework, emphasising movement's functional, formal, feeling-based, and flow-oriented dimensions. Drawing from participatory, observational, focus group, and interview data collected from vibrant senior living communities in SSHRC funded partnership with the International Council on Active Aging, the authors illustrate how older adults actively and interactively cultivate physical literacy beyond mere functionality. Through richly descriptive examples, including posture alignment classes, joyous cardio drumming sessions, and engaging recreational activities, the authors challenge ageist assumptions by highlighting older adults' capacity for movement that is socially connected, energetically vibrant, and intrinsically rewarding. A focus on interactive and relational dynamics extends the scope of physical literacy by emphasising collective joy and shared vitality. Researchers, practitioners, and community leaders are encouraged to shift physical activity programming towards more meaningful, community-oriented interactions, fostering sustained, joyful, and socially enriched participation across the lifespan.Type d'Item : Item , Physical Activity in Wellness Communities: Wisdom from ICAA NuStep Best in Wellness Award Winners(International Council on Active Aging, 2026-03-01) Belalcazar, Catalina; Lloyd, Rebecca; Smith, StephenThe article focuses on how physical activity programs in senior living communities can integrate all seven dimensions of wellness to support holistic aging. Topics include immersive research in award-winning communities, the integration of physical, social, emotional, intellectual, spiritual, vocational and environmental wellness, and practical design strategies for person-centered, community-based exercise programming.